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Neurodevelopmental Perspectives on Wnt Signaling in …

2017-1-13 · The originally described, and still molecularly best-characterized, "canonical" Wnt/β-catenin pathway hinges on regulated proteolysis of cytoplasmic β-catenin (Fig. (Fig.1a). 1a) the absence of Wnt pathway activation, the vast majority of β-catenin protein in a cell is localized to the submembranous space where it complexes stably with cadherin proteins involved in cell adhesion at ...

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2012-12-1 · II. Protein (/Lipid) Oxidation and Protein Dysfunction. OS induced by free radicals plays an important role in the pathophysiology of a wide variety of diseases including neurodegenerative disorders (63, 180) ee radicals are generated in vivo from various sources, one of the major sources being the leakage of superoxide radical from the mitochondria (Fig. 1).

Neurodevelopmental Perspectives on Wnt Signaling in ...

2017-1-13 · The originally described, and still molecularly best-characterized, "canonical" Wnt/β-catenin pathway hinges on regulated proteolysis of cytoplasmic β-catenin (Fig. (Fig.1a). 1a) the absence of Wnt pathway activation, the vast majority of β-catenin protein in a cell is localized to the submembranous space where it complexes stably with cadherin proteins involved in cell adhesion at ...

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